Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial.
Identifieur interne : 001911 ( Main/Exploration ); précédent : 001910; suivant : 001912Predictors of long-term outcomes in patients treated with riociguat for pulmonary arterial hypertension: data from the PATENT-2 open-label, randomised, long-term extension trial.
Auteurs : Hossein-Ardeschir Ghofrani [Royaume-Uni] ; Friedrich Grimminger [Allemagne] ; Ekkehard Grünig [Allemagne] ; Yigao Huang [République populaire de Chine] ; Pavel Jansa [République tchèque] ; Zhi-Cheng Jing [République populaire de Chine] ; David Kilpatrick [Australie] ; David Langleben [Canada] ; Stephan Rosenkranz [Allemagne] ; Flavia Menezes [Brésil] ; Arno Fritsch [Allemagne] ; Sylvia Nikkho [Allemagne] ; Marc Humbert [France]Source :
- The Lancet. Respiratory medicine [ 2213-2619 ] ; 2016.
Abstract
Pulmonary arterial hypertension is a chronic disease associated with poor long-term outcomes. Identifying predictors of long-term outcome in pulmonary arterial hypertension is important to assess disease severity and guide treatment. We investigate associations between efficacy parameters and long-term outcomes in patients with pulmonary arterial hypertension receiving riociguat in the PATENT-2 study. We also present safety and efficacy data from the final data cutoff of PATENT-2, where most patients had received at least 2 years of riociguat treatment.
DOI: 10.1016/S2213-2600(16)30019-4
PubMed: 27067479
Affiliations:
- Allemagne, Australie, Brésil, Canada, France, Royaume-Uni, République populaire de Chine, République tchèque
- Angleterre, Bade-Wurtemberg, Berlin, Bohême centrale, District de Karlsruhe, Grand Londres, Québec, État de São Paulo, Île-de-France
- Berlin, Heidelberg, Londres, Montréal, Orsay, Prague, Pékin, São Paulo
- Université McGill, Université Paris-Sud
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Electronic address: Ardeschir.Ghofrani@innere.med.uni-giessen.de.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Giessen and Marburg Lung Center (UGMLC) and German Centre of Lung Research (DZL), Giessen, Germany; Department of Medicine, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Grimminger, Friedrich" sort="Grimminger, Friedrich" uniqKey="Grimminger F" first="Friedrich" last="Grimminger">Friedrich Grimminger</name><affiliation wicri:level="1"><nlm:affiliation>University of Giessen and Marburg Lung Center (UGMLC) and German Centre of Lung Research (DZL), Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Giessen and Marburg Lung Center (UGMLC) and German Centre of Lung Research (DZL), Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Grunig, Ekkehard" sort="Grunig, Ekkehard" uniqKey="Grunig E" first="Ekkehard" last="Grünig">Ekkehard Grünig</name><affiliation wicri:level="3"><nlm:affiliation>Centre for Pulmonary Hypertension at the Thoraxclinic of University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Pulmonary Hypertension at the Thoraxclinic of University Hospital Heidelberg, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Huang, Yigao" sort="Huang, Yigao" uniqKey="Huang Y" first="Yigao" last="Huang">Yigao Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute, Guangzhou, Guangdong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Cardiology, Guangdong General Hospital and Guangdong Cardiovascular Institute, Guangzhou, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name><affiliation wicri:level="3"><nlm:affiliation>Clinical Department of Cardiology and Angiology of the First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Clinical Department of Cardiology and Angiology of the First Faculty of Medicine and General Teaching Hospital, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Jing, Zhi Cheng" sort="Jing, Zhi Cheng" uniqKey="Jing Z" first="Zhi-Cheng" last="Jing">Zhi-Cheng Jing</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Kilpatrick, David" sort="Kilpatrick, David" uniqKey="Kilpatrick D" first="David" last="Kilpatrick">David Kilpatrick</name><affiliation wicri:level="1"><nlm:affiliation>Discipline of Medicine, University of Tasmania, Hobart, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Medicine, University of Tasmania, Hobart</wicri:regionArea><wicri:noRegion>Hobart</wicri:noRegion></affiliation></author><author><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name><affiliation wicri:level="4"><nlm:affiliation>Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Rosenkranz, Stephan" sort="Rosenkranz, Stephan" uniqKey="Rosenkranz S" first="Stephan" last="Rosenkranz">Stephan Rosenkranz</name><affiliation wicri:level="1"><nlm:affiliation>Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne</wicri:regionArea><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion><wicri:noRegion>Cologne</wicri:noRegion></affiliation></author><author><name sortKey="Menezes, Flavia" sort="Menezes, Flavia" uniqKey="Menezes F" first="Flavia" last="Menezes">Flavia Menezes</name><affiliation wicri:level="3"><nlm:affiliation>Bayer HealthCare Pharmaceuticals, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Bayer HealthCare Pharmaceuticals, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fritsch, Arno" sort="Fritsch, Arno" uniqKey="Fritsch A" first="Arno" last="Fritsch">Arno Fritsch</name><affiliation wicri:level="1"><nlm:affiliation>Global Clinical Development, Bayer Pharma AG, Wuppertal, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Global Clinical Development, Bayer Pharma AG, Wuppertal</wicri:regionArea><wicri:noRegion>Wuppertal</wicri:noRegion><wicri:noRegion>Wuppertal</wicri:noRegion><wicri:noRegion>Wuppertal</wicri:noRegion></affiliation></author><author><name sortKey="Nikkho, Sylvia" sort="Nikkho, Sylvia" uniqKey="Nikkho S" first="Sylvia" last="Nikkho">Sylvia Nikkho</name><affiliation wicri:level="3"><nlm:affiliation>Global Clinical Development, Bayer Pharma AG, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Global Clinical Development, Bayer Pharma AG, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France; AP-HP, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France; Inserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, Université Paris-Saclay, Le Kremlin Bicêtre, France; AP-HP, Service de Pneumologie, Hôpital Bicêtre, Le Kremlin Bicêtre, France; Inserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson</wicri:regionArea><wicri:noRegion>Le Plessis Robinson</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory medicine</title><idno type="eISSN">2213-2619</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pulmonary arterial hypertension is a chronic disease associated with poor long-term outcomes. Identifying predictors of long-term outcome in pulmonary arterial hypertension is important to assess disease severity and guide treatment. We investigate associations between efficacy parameters and long-term outcomes in patients with pulmonary arterial hypertension receiving riociguat in the PATENT-2 study. We also present safety and efficacy data from the final data cutoff of PATENT-2, where most patients had received at least 2 years of riociguat treatment.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Canada</li><li>France</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>République tchèque</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>Bohême centrale</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Québec</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Heidelberg</li><li>Londres</li><li>Montréal</li><li>Orsay</li><li>Prague</li><li>Pékin</li><li>São Paulo</li></settlement><orgName><li>Université McGill</li><li>Université Paris-Sud</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ghofrani, Hossein Ardeschir" sort="Ghofrani, Hossein Ardeschir" uniqKey="Ghofrani H" first="Hossein-Ardeschir" last="Ghofrani">Hossein-Ardeschir Ghofrani</name></region></country><country name="Allemagne"><noRegion><name sortKey="Grimminger, Friedrich" sort="Grimminger, Friedrich" uniqKey="Grimminger F" first="Friedrich" last="Grimminger">Friedrich Grimminger</name></noRegion><name sortKey="Fritsch, Arno" sort="Fritsch, Arno" uniqKey="Fritsch A" first="Arno" last="Fritsch">Arno Fritsch</name><name sortKey="Grunig, Ekkehard" sort="Grunig, Ekkehard" uniqKey="Grunig E" first="Ekkehard" last="Grünig">Ekkehard Grünig</name><name sortKey="Nikkho, Sylvia" sort="Nikkho, Sylvia" uniqKey="Nikkho S" first="Sylvia" last="Nikkho">Sylvia Nikkho</name><name sortKey="Rosenkranz, Stephan" sort="Rosenkranz, Stephan" uniqKey="Rosenkranz S" first="Stephan" last="Rosenkranz">Stephan Rosenkranz</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Yigao" sort="Huang, Yigao" uniqKey="Huang Y" first="Yigao" last="Huang">Yigao Huang</name></noRegion><name sortKey="Jing, Zhi Cheng" sort="Jing, Zhi Cheng" uniqKey="Jing Z" first="Zhi-Cheng" last="Jing">Zhi-Cheng Jing</name></country><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Jansa, Pavel" sort="Jansa, Pavel" uniqKey="Jansa P" first="Pavel" last="Jansa">Pavel Jansa</name></region></country><country name="Australie"><noRegion><name sortKey="Kilpatrick, David" sort="Kilpatrick, David" uniqKey="Kilpatrick D" first="David" last="Kilpatrick">David Kilpatrick</name></noRegion></country><country name="Canada"><region name="Québec"><name sortKey="Langleben, David" sort="Langleben, David" uniqKey="Langleben D" first="David" last="Langleben">David Langleben</name></region></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Menezes, Flavia" sort="Menezes, Flavia" uniqKey="Menezes F" first="Flavia" last="Menezes">Flavia Menezes</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Humbert, Marc" sort="Humbert, Marc" uniqKey="Humbert M" first="Marc" last="Humbert">Marc Humbert</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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